Studies on Mechanism of Bactericidal Action by Irradiation with Radioisotope Cobalt-60

Studies on the use of cobalt-60 irradiation to control infectivity of Toxoplasma gondii cysts.

Mouse brains harboring the Chinese NT strain of Toxoplasma gondii cysts were homogenized with normal saline and irradiated with cobalt-60 gamma rays at various doses. The homogenate was introduced intraperitoneally into NIH mice or per os into kittens. Loss of infectivity was confirmed according to the following criteria: no cyst found in mouse brain impression smears on the 50th day after inoc...

Studies with Brugia pahangi. 15. Cobalt 60 irradiation of the worm.

Infective larvae of Brugia pahangi were irradiated at 10, 25 or 45 krads by means of a Cobalt 60 source. In cats, 10 krads caused the worms to be stunted and sterile but allowed them to become 5th stage, migrate posteriorly into the afferent lymphatic, and produce pathology. 25 krads prevented the worms from developing beyond the early fourth stage and from migrating away from the popliteal lym...

Cxxv. Studies on Selective Bactericidal Action

Mechanism of bactericidal action of aminoglycosides.

[This corrects the article on p. 341 in vol. 51.].

Studies of the Bactericidal Action of Phagocytin

The bactericidal activity of phagocytin on Gram-negative enteric bacilli is influenced by the reaction of the medium; the more acid the environment, the more marked is the activity. Phagocytin exerts approximately the same action whether citrate, acetate, or phosphate salts are used as buffer, and the addition of glucose, casein hydrolysate, or cation binding agents does not produce notable cha...